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Ionamin is generally well-tolerated. Adverse reactions have usually been mild and transient. In controlled clinical studies of 2502 patients, <2% of patients were discontinued due to adverse experiences attributable to Ionamin. The most frequent adverse events thought to be related to Ionamin were constipation, flatulence, dyspepsia, and abdominal pain.

 

Ionamin is used with diet changes to reduce the amount of cholesterol and certain fatty substances in the blood. It works by slowing the production of cholesterol in the body. Buildup of cholesterol and fats along the walls of the blood vessels decreases blood flow and, therefore, the oxygen supply to the heart, brain, and other parts of the body. Lowering blood levels of cholesterol and fats may help to prevent heart disease, angina, strokes, and heart attacks.

 

Ionamin as well as some of its metabolites are pharmacologically active in humans. The liver is the primary site of action and the principal site of cholesterol synthesis and LDL clearance. Drug dosage rather than systemic drug concentration correlates better with LDL-C reduction. Individualization of drug dosage should be based on therapeutic response.

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